In the clinic, we often meet fathers-to-be who come to see the semen report and ask, “Why does my semen take a long time to liquefy? Why does it take so long to liquefy?” Today, we will take expectant fathers who are preparing for pregnancy to understand what is going on with semen liquefaction and how this problem can affect couples who are preparing for pregnancy. Under normal circumstances, semen is thick and jelly-like after being ejected from the body under the action of coagulase secreted by the seminal vesicles, and then liquefied by the action of fibrinolytic enzymes secreted by the prostate gland after being ejected from the body, becoming thinner semen and liquefying into a watery liquid, this process is the liquefaction of semen, which is a normal physiological phenomenon. If semen is discharged from the body and remains jelly-like for more than 60 minutes, it is a pathological condition and is called semen non-liquefaction. So what causes this problem? First of all, we most commonly see infections of the urinary system, such as prostatitis and vesiculitis; the prostate gland produces proteolytic enzymes, lysozyme and other semen liquefaction factors that cause semen to liquefy. Once inflammation occurs in the prostate, the secretion of the above factors can be impaired and the liquefaction factors can be reduced, resulting in semen non-liquefaction disorder. The coagulation factors produced by the seminal vesicles cause the semen to coagulate. Once the seminal vesicles become inflamed, the secretion of the above factors may be impaired, resulting in an increase in coagulation factors and the formation of semen non-liquefaction. Secondly, it has been reported in the literature that deficiencies of trace elements, such as magnesium and zinc, can also lead to the symptoms of semen non-liquefaction. The sperm in this semen is obviously obstructed in the female reproductive tract, and the sperm cannot run, cannot cross the cervical canal, cannot enter the uterine cavity and fallopian tubes, and cannot meet the egg, resulting in infertility in the female partner. After we understand the problem, the fathers-to-be can make targeted and positive preparations. We suggest: 1. to enhance their physical strength and improve the quality of sex life; 2. to supplement zinc and selenium elements, amino acids and improve the prostate gland so that the quality of sperm and eggs can be improved; 3. we can improve microcirculation, promote blood flow and flow, and improve the oxygen supply and oxygen capacity of human tissue cells . This allows the sperm to have enough nutrients, which in turn improves the quality of the sperm. Finally, for those who are indeed caused by inflammatory infections such as prostatitis patients should actively treat the cause and choose antibiotics that have a high concentration of lipid soluble, alkaline, broad antibacterial spectrum that are also effective against mycoplasma and chlamydia is appropriate.