Swelling and pain behind the ear, may be behind the ear lymph node inflammation, acute mastoiditis and other diseases caused by oral medication, can follow the doctor’s instructions to choose sensitive antibiotics, anti-inflammatory analgesic drugs. 1. Post-auricular lymphadenitis: you can take amoxicillin, cefixime and other antibiotics to fight infection, together with ibuprofen, celecoxib and other anti-inflammatory analgesic drugs, to alleviate the symptoms of pain. 2. Acute mastoiditis: you can take oral cefadroxil tablets, ofloxacin capsules and other antibiotics to fight infection, with acetaminophen, diclofenac sodium and other anti-inflammatory analgesic drugs to relieve pain. If the swelling and pain behind the ear is serious, or if you need to take measures such as surgical treatment, it is recommended that you go to the hospital for examination first, to clarify the cause of the disease, and follow the doctor’s instructions to standardize the use of drugs and treatment.