Submucosal elevation of the ascending colon is mostly a benign lesion. It is recommended to go to the gastroenterology department of the hospital for examination to further clarify the diagnosis. Colonic mucosal bulge is a description of colonic mucosal bulge during colonoscopy. There are many reasons for submucosal elevation, such as inflammation, infection, hyperplasia, lymphatic hyperplasia, in addition to benign tumors and malignant tumors may also lead to submucosal elevation. It is recommended to check again with the doctor’s advice, such as enteroscopy and ultrasonic endoscopy, which can measure the depth of infiltration of submucosal lesions and understand the scope of the lesions. If necessary, pathologic examination can be performed to clarify the nature of the elevated lesion. In most patients, submucosal elevations of the colon are caused by benign lesions. In a very small number of patients, it may be caused by malignant tumors. It is recommended to clarify the diagnosis, combined with the doctor’s advice, to give treatment for the cause of the disease.