Insomnia in patients with uremia needs to be treated symptomatically and causally by general measures, medication, surgery and other treatments. 1. General measures: cognitively adjust the attitude towards insomnia, not overly concerned about it, and behaviorally cooperate with the doctor to conduct professional relaxation training to intervene in insomnia. It is also necessary to adjust the diet structure, limit the intake of protein, salt and potassium, and pay more attention to rest. 2. Drug therapy: insomnia symptoms are more serious need to comply with medical advice to use eszopiclone and other benzodiazepine drugs. For uremia there is metabolic acidosis, need to follow the doctor’s advice to use sodium bicarbonate; for water, sodium balance imbalance, uremia patients need to follow the doctor’s advice to use furosemide, hydrochlorothiazide and other diuretics; for calcium and phosphorus imbalance of uremia patients need to follow the doctor’s advice to use calcium carbonate and other phosphorus binding agent. 3. Surgery: If the condition of uremia patients is serious and there are indications for surgery, then kidney transplantation should be considered. 4. Other treatments: Secondly, insomnia can be treated with transcranial electrical stimulation, transcranial magnetic stimulation, light therapy and other treatments. In addition, uremia patients need to cooperate with doctors to take blood purification treatment, such as peritoneal dialysis, hemodialysis. To summarize, it is recommended that patients go to regular hospitals in a timely manner, under the guidance of the doctor to take appropriate treatment measures, medication should be used in accordance with the doctor’s instructions, do not self-medication.