Weight gain in diabetic patients should be analyzed from two situations: the first situation, the patient just discovered diabetes, in the time of getting diabetes due to the consumption of high blood sugar, the patient’s weight loss is more obvious, after effective glucose-lowering treatment after better control of blood sugar, weight will be significantly more than before, suggesting that the current diabetes is relatively well controlled, glucose-lowering treatment is effective. The second situation is the effect of glucose-lowering drugs, such as sulfonylureas, insulin, etc., common side effects in addition to hypoglycemic islets there is weight gain. Therefore, for the use of related drugs caused by weight gain need to be a comprehensive assessment of the condition, when necessary to adjust the drug regimen.