Diffuse changes in the liver with splenomegaly indicate passive bruising and enlargement of the spleen due to progression of chronic liver disease to cirrhosis and portal hypertension of cirrhosis; polypoid lesions of the gallbladder indicate protruding or bulging lesions into the lumen of the gallbladder. 1. Diffuse hepatic changes: liver disease progresses to a pathological stage characterized by diffuse fibrosis, pseudofollicularity, regenerative nodules and intra- and extra-hepatic vascular proliferation, i.e., the cirrhotic stage. 2. Enlargement of spleen: when the liver develops portal hypertension due to cirrhosis, the venous return of spleen is obstructed, resulting in the reversal of portal venous pressure to the spleen, which makes the spleen passively bruised and enlarged, and the splenic tissues and intra-splenic fibrous tissues proliferate. 3. Polypoid lesions of gallbladder: mostly benign, pathologically divided into neoplastic and non-neoplastic. The former includes adenomas and adenocarcinomas, while the latter includes cholesterol polyps and inflammatory polyps, which may be combined with cholecystitis and gallbladder stones. If there is diffuse enlargement of the liver, enlargement of the spleen and gallbladder polyps, it is necessary to seek medical treatment as soon as possible to avoid further aggravation of the disease.