When hearing that craniotomy is required, people are undoubtedly afraid of the risks, but in fact craniotomy is quite common in neurosurgery, and the technology is quite mature after a long time of development. For example, if there is a serious traumatic brain injury or a serious craniosynostosis, these may require craniotomy. There is an important part in craniotomy, that is, when the patient has intracranial hypertension is required to decompression of the large bone flap, craniotomy decompression sequelae are what? This is a noteworthy issue, patients will be left with cranial defects after decompression of the large flap, sometimes combined with a series of cranial defect syndrome, such as headache, dizziness, irritability, epilepsy, unexplained discomfort and various mental disorders, etc. When it comes to the skull, it is like the protective membrane of the brain, and once the skull defect has a certain impact on health, so when the skull defect is larger than 3cm in diameter, it is recommended that patients undergo skull repair surgery about 3 months after surgery. At present, many hospitals can carry out skull repair surgery, but it is not easy to do it well, especially to choose good skull repair materials. Nowadays, titanium mesh material is widely used in the clinic. Titanium mesh material is progressive to some extent, but it also has some shortcomings, such as low strength, poor shaping, easy infection and rejection after surgery, sensitivity of the affected area to external hot and cold environment, affecting postoperative medical examination, etc. Compared with titanium meshz material, the polyether ether ketone peek material used now is much more ideal, which is an advanced polymer material, its various properties are very close to the autologous cranial bone, and if necessary, the concept of cosmetic plastic surgery can be introduced in the operation, not only can highly restore the anatomical structure of the skull, the postoperative effect looks more natural and beautiful.