Substantial breast lumps are usually considered as breast ductal papilloma, breast fibroma, breast cancer, etc. 1. Mammary ductal papilloma: Intraductal papilloma generally refers to benign tumors occurring in the epithelium of the mammary ducts, with a higher incidence rate. Clinical manifestations are mostly nipple discharge and breast lump, the discharge is persistent or intermittent, sometimes accompanied by pain or inflammation. 2. Breast fibroma: the symptoms of breast fibroma are mainly painless nodules, this kind of lump is generally clearer boundary, softer texture, movable. Especially for young women, painless nodular lumps are mostly caused by high estrogen level of patients. 3. Breast Cancer: Breast cancer may not have obvious symptoms in the early stage, but when doing breast examination, most of them will find substantial lumps in the breast, and the edges of the lumps are irregular, not smooth, and the texture is hard. The cause of the disease is still unclear, mostly due to genetic factors, living environment, physical function disease and other factors. Substantial breast lumps can also be caused by other reasons, when you find abnormalities in the body should consult a doctor in time, to clarify the cause of the disease, and then actively treat it.