Felodipine extended-release tablets and Irbesartan cannot be assessed as to which is better, depending on which drug is more suitable for the patient’s disease characteristics. Felodipine extended-release tablets play an additive role by inhibiting the inward flow of calcium ions, which is more suitable for middle-aged and elderly patients, both to reduce blood pressure levels, but also to increase the supply of blood to the coronary arteries. Adverse effects of felodipine extended-release tablets include constipation, ankle edema, palpitations, facial flushing, etc. It is contraindicated in patients who are allergic to the drug ingredients or have low blood pressure. Irbesartan belongs to the role of angiotensin II receptor antihypertensive drugs, for hypertension accompanied by renal insufficiency, cardiac insufficiency patients with better results. Irbesartan’s adverse reactions include postural dizziness, postural hypotension, skin rash, etc. Irbesartan is contraindicated in patients who are allergic to the components of the drug, have severe renal impairment, or are in the middle or late stages of pregnancy or breastfeeding. Felodipine extended-release tablets and Irbesartan are both commonly used in clinical applications, each drug has its own characteristics, suitable for different patients, according to each patient’s own characteristics of the selection of the appropriate drug, it is impossible to assess the effect of the drug is better.