Cyclic vomiting syndrome is potentially curable. Cyclic vomiting syndrome is a psychiatric disorder characterized by periodic or recurrent episodes of severe nausea and vomiting with no symptoms in the intervals and no organic disease underlying the disorder. It is most common in children, but can also be seen in adults. Its etiology and pathogenesis have not been fully clarified, and there is no effective treatment at present. Acute vomiting episodes should be based on rehydration, maintenance of water and electrolyte disorders, in the acute vomiting episodes can be applied to 5-hydroxytryptamine 3-receptor antagonist intravenous antiemetic, while the use of sedatives (such as lorazepam) or antihistamines (such as phenylephrine) is more effective. In remission it should be treated by reducing the frequency of vomiting episodes, along with psychotherapy. After active and effective treatment, patients with cyclic vomiting syndrome can be cured by avoiding triggering factors such as infection, motion sickness and psychological stress in daily life. Reasonable sleep and diet, appropriate application of anti-migraine drugs (cyproheptadine, propranolol, amitriptyline, mirtazapine), antiemetic drugs (aripitant), antiepileptic drugs (phenobarbital, topiramate) and so on can prevent attacks. Patients diagnosed with cyclic vomiting syndrome should actively cooperate with their doctors.