Sleeping chest tightness and congestion may be due to autonomic dysfunction, myocardial ischemia, bronchitis, etc. It is recommended to give glutamine, nitroglycerin or salbutamol according to the cause of the drug treatment. 1. Autonomic dysfunction: Most of the syndromes are caused by prolonged mental tension, excessive psychological pressure and other stimulation of the nerves. It is mainly characterized by difficulty in falling asleep at night, accompanied by symptoms such as chest congestion and shortness of breath. Treatment is mainly based on psychotherapy, with the use of glutamine, vitamin B1 and other drugs to regulate autonomic function. 2. Myocardial ischemia: when suffering from coronary heart disease, arrhythmia and other cardiogenic diseases, coronary artery blood flow is interrupted and distal blood volume is reduced, which will lead to myocardial ischemia. It can be manifested as the symptom of chest tightness and shortness of breath, and the chest tightness and congestion will be aggravated especially in the evening when sleeping. Nitroglycerin, isosorbide nitrate and other nitrate drugs can be applied to reduce the recurrence of myocardial ischemia. 3. Bronchitis: Bronchitis is induced by recurrent infections of viruses and bacteria, and the blockage of airways can trigger symptoms of chest tightness and shortness of breath. Lack of oxygen will aggravate the symptoms of chest tightness and congestion when sleeping at night due to insufficient arterial oxygen saturation. For treatment, receptor agonists such as salbutamol and formoterol can be applied to dilate the bronchial tubes and relieve airflow limitation. If chest tightness occurs frequently during sleep, it is recommended to go to the hospital to exclude cardiogenic and respiratory diseases, and to improve ECG, cardiac enzymology and other tests. Please do not self-medicate, and should be diagnosed and treated under the guidance of a doctor.