The current treatment for Parkinson’s disease is still more effective with both systemic drug therapy and surgery. It should be emphasized that when surgical treatment is performed, it is important to carefully distinguish whether the patient has Parkinson’s disease or Parkinson’s syndrome, as there are considerable differences in the treatment and prognosis of the two. First, the causes of the disease are different. Parkinson’s syndrome is generally caused by other diseases of the nervous system, such as cerebrovascular disease, traumatic brain injury, intracranial inflammation, brain tumors, or by toxic substances or drugs, while the pathological changes in Parkinson’s disease are mainly degeneration of dopamine neurons in the substantia nigra of the midbrain, resulting in the inability to produce sufficient dopamine and the onset of the disease. Second, the treatment methods are also different. In terms of drug treatment, levodopa replacement drug therapy for Parkinson’s disease plays a better role, while it is less effective for Parkinson’s syndrome. For surgical treatment, surgery is generally not recommended for Parkinson’s syndrome patients, because even surgery for Parkinson’s syndrome patients will not achieve long-term therapeutic effects, but only temporary remission, while Parkinson’s disease is suitable for surgical treatment, and the surgical effect is also very significant! For patients in the early stages of Parkinson’s disease, medication is still the most basic treatment method, medication has a significant effect on the treatment of Parkinson’s disease, but medication has two major drawbacks, one is that the blood-brain barrier inside the human brain will block part of the drug absorption, if the dosage is increased, and the surrounding nervous system will produce very One is that the blood-brain barrier in the human brain blocks part of the absorption of the drug, and if the dosage is increased, it will have a very obvious toxic side effect on the peripheral nervous system, which will be intolerant over time! The other is that the dopamine replacement provided by the drug instead inhibits the patient’s body from producing the substance itself. The best surgical treatment for Parkinson’s disease is DBS (Deep Brain Stimulation). For patients with intermediate to advanced disease, surgery is the best option when medication is no longer sufficient to control the disease. The best surgical treatment is DBS (Deep Brain Stimulation), commonly known as a brain pacemaker. This method involves doctors implanting a high-frequency stimulation electrode thinner than a ball-point pencil into a specific part of the patient’s brain to suppress tremors in Parkinson’s patients when certain parts of the brain are stimulated by electric currents. The pacemaker can continuously send out high-frequency pulses of electrical stimulation, and the important thing is that the installed pacemaker can be surgically removed at any time without any damage to the human structure. The most critical and difficult step in the surgery is to find the exact positioning point to put the electrodes in. “The head is like a very complete watermelon, a watermelon seed in the middle of the watermelon, how to open only a small hole in the eye to accurately find the seed you need, if you do not find the precise location, on the one hand, there is no effect, on the other hand is to bring other side effects. In addition, in order to find the precise location, MRI technology is used before the surgery to determine the location of the surgery, and this location cannot be more than 1 mm error. As the human brain is wrapped by cerebrospinal fluid, when a small hole of 1 cm is opened in the patient’s head, a small amount of cerebrospinal fluid often flows out, and under the effect of gravity, some patients’ brains will sink about 1 mm, and if the electrodes are still installed according to the original plan, there will be errors and the surgery will not achieve the best results. In order to avoid such errors, the world’s most advanced intraoperative MRI instrument is used In order to avoid such errors, the most advanced intraoperative MRI in the world was used, and after the initial installation of the electrodes, the patient’s brain was scanned again to observe the implantation position, which made the surgery extremely accurate. As for the application of precision medicine in the field of Parkinson’s disease treatment, in fact, the focus of precision medicine is on the word “precision”, as mentioned above, how to precisely find the positioning point of electrode placement is the best embodiment of precision medicine. Although the DBS method does not damage the brain structure and leaves a lot of room for future methods to cure Parkinson’s disease. However, this procedure is still not a radical cure for Parkinson’s disease. The only way to treat Parkinson’s disease is to address the root cause of Parkinson’s disease. Stem cell transplantation is a direction to cure Parkinson’s disease, note, a direction! The pathogenesis of Parkinson’s disease is the damage of neurological cells, resulting in the reduction of a substance called dopamine. Now the study of stem cell transplantation to replace the damaged cells is the fundamental solution to the problem of the future for the complete cure of Parkinson’s disease stem cell transplantation is a direction, there has been a lot of progress, but the application of clinical there is still a distance. First, how to distinguish the damaged cells and precisely plant them on the damaged cells; second, whether they can secrete the required amount of dopamine; and finally, how to control the growth quantity and speed of the implanted cells. Once these problems are solved, Parkinson’s disease and neurodegenerative diseases of the middle-aged and elderly will be solved. As this new technology is still under research and has not been applied to clinical treatment, Parkinson’s disease patients should not be misled by the names of technologies such as bio-interventional regenerative therapy and 3N neuroprosthetic therapy, and must choose a regular hospital for treatment in the face of new technologies and new treatments. To avoid misdiagnosis and delay in the next step of treatment by believing in some prescriptions and advertisements.