Whether a 25mm×25mm renal cyst needs to be treated or not depends mainly on the condition of the cyst. In most cases, cysts do not cause clinical symptoms and do not require special intervention; some cysts associated with infection can be treated with anti-infective therapy; a small number of cysts can cause pressure on the adjacent renal pelvis and ureter, which requires surgical treatment. 1. Most of the small-sized renal cysts do not have any effect on the physical condition and do not cause clinical symptoms, so they do not need special intervention and only need regular checkups. 2. When cysts are associated with infection, causing localized fever and low back pain, anti-inflammatory drugs can be applied for treatment, and commonly used drugs include cefixime and so on. 3. If the cyst presses on the neighboring tissues and causes abnormal urination, the cyst can be treated by minimally invasive surgery with decapitation and drainage. If the cyst itself is 25mm×25mm and has back pain or continues to increase in size, it is necessary to consult a doctor in time for observation and standardized treatment under the guidance of a clinician.