Eyelid swelling after getting up from sleep may be related to physiological factors, or it may be caused by blepharitis, allergic conjunctivitis, nephritic edema and so on. 1. Physiological factors: If the patient stays up too late at night, has insomnia or drinks too much water before going to bed at night, it may cause the patient to have swollen eyes after getting up from bed, which is mostly a physiological factor, and usually does not require special intervention and can be relieved after rest. 2. Blepharitis: Blepharitis is often associated with poor eye hygiene, such as frequent rubbing of the eyes with dirty hands, contact lens contamination, not removing makeup and other reasons, resulting in acute suppurative inflammation of the patient’s eyelid glands. Patients may have red and swollen eyelids, conjunctival congestion, photophobia, eyelid pain and other uncomfortable symptoms. 3. Allergic conjunctivitis: allergic patients because of sleeping on the contact of the pillowcase, duvet cover and other allergies, after waking up, the eyelids may be swollen, but also eyelid itching and other uncomfortable symptoms. 4. Kidney disease: glomerulonephritis, nephrotic syndrome and other diseases, because of the decline in renal function, resulting in more water in the body can not be discharged, the patient may appear eyelid swelling, may also appear lower limb edema. It is recommended that patients with obvious eyelid swelling should consult a doctor to evaluate their condition and follow the doctor’s instructions to choose the appropriate treatment.