Knee and ankle pain is commonly associated with degenerative osteoarthritis, rheumatoid arthritis, and rheumatoid arthritis, as follows: First, degenerative osteoarthritis: a common disease of the elderly, patients will have knee and ankle pain and limited movement, and symptoms will worsen when walking with weight and going up and down stairs, and will decrease when resting. X-rays will reveal joint osteophytes and joint space narrowing, and MRI will show degenerative damage to joint cartilage. Secondly, rheumatoid arthritis and rheumatoid arthritis: it may manifest as knee and ankle joint pain and restricted movement, accompanied by joint stiffness in the morning. Rheumatoid arthritis can also cause serious joint deformity and joint function damage, while rheumatoid arthritis only shows acute pain and limited activity, and does not cause joint deformity and function damage. Pain in the knee and ankle should be seen and treated promptly to relieve the painful symptoms.