Some hepatitis B is reversible. In adults with acute hepatitis B infection, more than 90% of the cases can be converted to negative. However, most chronic hepatitis B patients cannot be cured with the current level of medical care, which means that the surface antigen of hepatitis B is generally impossible to turn negative, but there are a few patients who have turned negative for the surface antigen of the hepatitis B virus in clinical practice. In the first case, the hepatitis B virus is completely cleared by the antiviral treatment and the strong immune system of the patient. The second type, the natural transformation, a few chronic hepatitis B patients due to their own immune function is strong, a number of years after the natural full healing, that is, hepatitis B turned negative.