Always wake up in the middle of the night may be caused by sleep environment factors, mental psychological factors or physical disease factors. 1. Sleep environment factors: always wake up in the middle of the night sleep environment of the noisy, light, humidity, temperature is not suitable to cause sleep always wake up. 2. Psychological factors: patients may be nervous, excessive anxiety, or recent stress, will affect the quality of sleep, often wake up in the middle of the night. Need to self-regulate their emotions, if there is no significant improvement or impact on life to the regular hospital for diagnosis and intervention. 3. Physical disease factors: people always wake up in the middle of the night also need to consider sleep apnea syndrome, cardiac insufficiency, asthma, coronary heart disease and other physical diseases. If the symptoms of waking up in the middle of the night do not improve, you should consult a doctor in time, under the guidance of the doctor to identify the cause of the active treatment, to avoid delaying the condition.