Negative inotropic effect refers to the inhibition of myocardial contractility, decreased oxygen consumption, and delayed conduction of myocardial cells, which serves to promote vasoconstriction and diastole and improve myocardial ischemia. Negative inotropic effects are usually carried out through drugs, such as carvedilol tablets and verapamil hydrochloride tablets, which can produce negative inotropic effects on the body. Patients who need to apply these medications should use them appropriately under the guidance of a doctor. Patients should consult their doctors before using the drugs to clarify whether the negative inotropic effect produced by the drugs is therapeutic or a side effect. If it is therapeutic, the drug can be used to treat diseases such as myocardial ischemia. If it is a side effect of the drug, it may cause the patient’s symptoms of heart failure to worsen. Patients should monitor their heart rate and blood pressure regularly while on the medication, and seek medical attention if the negative inotropic effects make them unwell.