Resorcinol and scopolamine are both widely used antispasmodic painkillers in clinical practice, it is not possible to specify which one is more effective, and it is necessary to choose the one that is more suitable for the patient. 1. Resorcinol: is a pro-muscular, non-atropine, non-papaverine smooth muscle antispasmodic drug, the drug only acts on the spasm of smooth muscle, can effectively relieve pain, spasm. It does not have an anticholinergic effect, does not have a strong effect on the patient’s cardiorespiratory function, does not cause arrhythmia, dry mouth and other symptoms, and rarely has an allergic reaction. Nursing women and pregnant women should avoid using this drug. 2. Scopolamine: the mechanism of action is based on anticholinergic, mainly used for gastrointestinal colic, biliary tract spasm, acute microcirculatory disorders and organophosphorus poisoning and other diseases, often used in conjunction with other drugs to assist in the treatment of certain diseases. The side effects of scopolamine include dry mouth, red face, increased heart rate, difficulty in urination, etc. It is contraindicated for those with ocular abnormalities, malignant tumors, pregnant women, and enlarged prostate. Resorcinol and scopolamine have their own advantages in clinical application, but the use of medication should follow the principle of individualization, and should follow the doctor’s instructions to choose the appropriate drug.