The pathogenesis of psoriasis has not been completely clarified, and there is no optimal clinical treatment at present. The treatment mainly includes local topical drugs, systemic therapy, biological agents, photochemotherapy and so on. 1. Topical drugs: topical drugs for psoriasis include calcium-modulated phosphatase inhibitors such as tacrolimus ointment, vitamin D3 derivatives such as calcipotriol ointment, glucocorticoid ointment such as fluticasone propionate ointment, and tar and salicylic acid, which need to be used in accordance with the condition of patients and the instructions of doctors. 2. Systemic therapy: Oral medications include immunosuppressants such as methotrexate and cyclosporine, and retinoids such as avitamin A, which can regulate epidermal differentiation and have anti-inflammatory effects. 3. Biological agents: Biological agents, including adalimumab, ezekizumab, guselizumab, etc., can block the body’s abnormal immune response that leads to psoriasis symptoms. 4. Photochemotherapy: Photochemotherapy, such as ultraviolet light irradiation, can suppress the immune response if necessary. To summarize, there is no best way to treat psoriasis. Patients with psoriasis are advised to choose the appropriate treatment plan under the guidance of their doctors.