Waking up with blood in the nose can be caused by rupture of nasal mucosa, deviated nasal septum, nasal hemangioma, etc., which can be treated by improving indoor humidity and surgery. 1. Nasal mucous membrane rupture: mainly due to the dryness of the room or excessive digging of the nostrils caused by the rupture of the nasal mucous membrane, at this time you can improve the indoor humidity, try not to dig the nostrils and other ways to relieve, if necessary, you can consult a doctor to stop bleeding. 2. Deviated nasal septum: Generally, it does not need special treatment, but if there are symptoms such as nosebleed and poor nasal breathing, it can be relieved by nasal septum surgery. 3. Nasal hemangioma: Generally, you can stop bleeding by local pressure, and if necessary, you can be treated by surgical resection. There are other possibilities for waking up with a bloody nose, so it is recommended to consult a doctor in time to improve the relevant examinations and standardize the treatment.