The treatments for lung large cell carcinoma include surgery, chemotherapy, radiotherapy, targeting, immunization and so on. Surgery is the best and the only cure for large cell lung cancer, so patients who have the chance to undergo surgery should actively undergo surgery. Chemotherapy is also an important means, which can reduce the difficulty of surgery, improve the efficacy after surgery, and prolong the survival period of patients with advanced stage. Radiotherapy is mainly used for patients who cannot be operated, have residuals after surgery, or have bone metastases, and is often used in combination with chemotherapy and targeted therapy. Targeted therapy is mainly applied to patients with late stage and sensitive to targeted therapy by genetic testing, especially patients with poor results of chemotherapy, which can further prolong the survival of patients. Immunotherapy is mainly applied to patients with poor results of other treatments in advanced stages, which can improve the quality of life and prolong the survival of some patients.