Clean surgery is not considered prophylactic medication for pregnant women, breastfeeding women, children, the elderly, and those with poor liver and kidney health. Clean surgeries include thyroid, breast, bone and joint surgeries, and these wounds will not have bacteria. People who do not consider prophylactic use of the drug are pregnant women, pregnant women who use the drug may have an impact on the development of the fetus, and are prone to preterm labor, miscarriage, and fetal malformations. For breastfeeding women, if the drug is used, there is a possibility that the drug may enter the baby’s body through breast milk and cause liver and kidney damage or adverse reactions. Preventive use is not recommended for children because of immature organ development. For the elderly with poor liver and kidney function, the use of the drug may cause organ damage to aggravate. Therefore, for clean surgery in general, do not consider the use of prophylactic drugs, especially for special populations, if you have to use need to weigh the pros and cons.