Heavy stubborn blackheads can go to regular hospitals for needle clearing, acid brushing and medication. Blackheads are open pimples, caused by partial oxidation of the surface of the oil plugs, and the accumulation of lipid secretions or inflammatory necrotic tissues within them, which cannot be discharged. Severe stubborn blackheads can be discharged by using needle clearing in regular hospitals, and can also be treated with peeling agents such as fruit acid and salicylic acid. In addition, you can follow the doctor’s instructions to take isotretinoin to inhibit the sebaceous gland lipid secretion, regulating the follicle sebaceous gland duct keratinization. Patients with severe stubborn blackheads should go to the hospital and be treated under the guidance of a professional doctor. Normally, you should carry out regular deep cleansing, and use skin care products appropriately after washing your face to improve enlarged pores.