Patients with edema of the lower limbs and eyelids are mostly caused by kidney disease, cardiovascular disease, liver disease and anemia. 1. Kidney disease: patients with kidney disease may have edema of the lower limbs and eyelids, such as patients with nephrotic syndrome because of large amounts of proteinuria leading to hypoproteinemia, which can lead to body edema, eyelids are more pronounced, and edema of both lower limbs can also occur. 2. Cardiovascular disease: when patients have heart failure, it may lead to pulmonary circulation stasis and body circulation stasis, resulting in sodium retention in the body, which leads to edema of the lower limbs and eyelid edema. 3. Liver disease: patients with liver disease, such as chronic hepatitis, may lead to cirrhosis, liver dysfunction reduces protein production, and patients may have ascites and edema of eyelids and lower limbs. 4. Others: In addition, patients with severe malnutrition and moderate-to-severe anemia may also have swollen eyelids and lower extremities. It is recommended that patients with eyelid and lower extremity edema should seek medical attention to evaluate their condition and follow the doctor’s instructions.