Patients with uremia may have abnormalities in their own coagulation function, including a tendency to bleed, due to a range of problems such as toxin retention, which is related to poor platelet function, suppressed bone marrow, and insufficient platelet production in patients with the uremic state. In this state, patients with uremia have imbalances in the coagulation and fibrinolytic systems and reduced production of coagulation factors, all of which can lead to a tendency to bleed. Uremic patients generally have poor vascular endothelial function and elevated blood pressure, especially after entering the hemodialysis stage, patients need to use long-term heparin or low-molecular heparin anticoagulation, which will lead to bleeding more easily. Therefore, patients with uremia need to undergo early laboratory tests for the cause of the disease and actively treat the cause of the disease.