Tummy ache is seen in many kinds of diseases, need to clarify the cause, choose the targeted treatment plan. Simple gastroenteritis can be treated with oral anti-inflammatory drugs, applying cephalexin tablets or levofloxacin tablets, and attention should be paid to physical therapy (such as hot compresses), all of which can relieve the patient’s discomfort. Many adults are suffering from diseases of the biliary system, such as cholecystitis and gallbladder stones, which can manifest as pain in the right side of the upper abdomen, as well as significant gastrointestinal irritation such as fever. The most effective treatment is the option of surgery to remove the gallbladder. For mild cases, patients can also get better with conservative treatment methods, choosing a broad-spectrum cephalosporin combined with metronidazole given intravenously. During treatment, it is also important to monitor changes in laboratory indicators and to pay attention to a fluid-based diet, as well as symptomatic treatment such as water fasting, intravenous fluid supplementation, and nutritional support if necessary. There are many diseases that are generally differentiated from abdominal pain, so a clear diagnosis is needed.