Dry and cracked toes can occur in diseases such as psoriasis vulgaris, tinea pedis, chronic eczema, etc. Symptomatic treatment is needed. Dimethicone oil or zinc oxide borate ointment can be applied to moisturize the skin as well as anti-inflammatory and anti-allergic therapeutic effects. At the same time, active treatment of the primary disease, if it is caused by psoriasis, can be combined with oral administration of compound amineptine tablets, combined with compound glycyrrhizin capsules, and topical application of a mixture of dinaide ointment or carbotriol ointment. If it is caused by eczema, oral levocetirizine hydrochloride oral solution and topical hydrocortisone butyrate ointment can be used. If it is caused by tinea pedis, you can take oral terbinafine hydrochloride tablets and apply topical bifenazole ointment for antifungal treatment.