Cranial repair surgery is a classic and routine surgery in neurosurgery, which is performed to repair cranial defects caused by various reasons, to remodel the complete and closed cranial cavity, to restore and improve the neurological function, and to prevent various cranial defect syndromes. Due to the high incidence of cranial defects, cranial bone repair has been widely performed in recent years, and the technology is very mature, and the repair materials are also constantly being innovated. The selection of cranial bone repair materials has a great influence on the repair effect. At present, there are two main types of cranial bone repair materials used in the clinic, one is the traditional titanium alloy material, but the new polyether ether ketone PEEK material. Titanium alloy material may be relatively more widely used in the clinic, and probably most neurosurgery departments in general hospitals use repair materials that are generally titanium alloy mesh or titanium alloy plate when carrying out cranial bone repair surgery. However, titanium alloy materials are not ideal, and various problems and defects often occur in clinical use. For example, the titanium plate is exposed after cranial repair, which is often referred to as material exposure. There are several reasons for this kind of titanium plate exposure: one is that it may be related to the material rejection reaction, that is, the titanium plate material is incompatible with the patient’s tissues, causing abnormal immune reaction of the patient’s body, back to their own scalp tissues, resulting in scalp breakage and material exposure; another important reason is that the edge of the titanium plate material is relatively sharp, which may cause abrasion or cutting damage to the scalp tissues, and over time, the scalp will break and the titanium alloy material will be damaged. Another important reason may be that the edges of the titanium plate material are sharp, causing abrasion or cutting damage to the scalp tissue, and over time, the scalp will break and the titanium alloy material will be exposed. In addition to material exposure, there are many other problems with titanium plate or mesh materials, such as heat and cold sensitivity, collapse and deformation under stress, impact on CT and MRI, poor contouring, etc. Our team is now using a new type of titanium alloy material that has been widely used in the field of plastic surgery for many years. At present, our team is widely using the new polyether ether ketone PEEK as the cranial bone repair material. Director Mu introduced, polyether ether ether ketone is a special polymer material, excellent performance, and autologous skull is basically equivalent, can effectively avoid postoperative infection, rejection, wear and tear of the scalp and other conditions, to prevent the exposure of the material, there will be no heat and cold sensitivity reaction, deformation of the collapse of the force, affecting the CT nuclear magnetic examination, etc., and in addition, the polyether ether ketone through the design of the three-dimensional reconstruction, 3D printing production, highly restore the structure of the skull, molding The effect is very good. In addition, the team constantly improves and upgrades the technology and optimizes the design of materials, and also innovatively introduces the concept of cosmetic plastic surgery, which not only repairs the integrity of the defective skull, but also carries out cosmetic plastic surgery on factors affecting the appearance to achieve the good results of anatomical integrity, structural restoration, perfect function and beautiful appearance, which is highly praised and recognized by the majority of patients.