Cold erythema multiforme, also called erythema multiforme frostbite, is a type of erythema multiforme-like skin damage. 1. Erythema multiforme frostbite is caused by cold. Skin lesions are mostly seen on the face, ears, limbs and these distal parts, but also on the ankles, extensor side of the knee, thighs, buttocks and waist. This disease is more frequent in the cold season, mostly seen in women, the disease can be repeated, the course of the disease can be a few days or up to several years. 2. Clinical manifestations: in the cold season, the face, ears, limbs, distal end of the exposed parts, there will be edematous papules, mung bean or soybean size dark red rash, some of the center will also have blisters. The middle color of the skin damage is dark red or purplish red, and the itching sensation will be more obvious after the surface temperature of the skin rises. 3. Prevent the onset of the disease in the cold season of winter and spring, pay attention to the cold and warmth, the exposed parts of the body and the end parts of the limbs should wear warm items. Don’t wear over tight shoes and socks. Should strengthen exercise, enhance their physical fitness, improve the body’s own immunity. It is recommended that patients consult a doctor in a timely manner and standardize the treatment under the guidance of the doctor.