Whether creatinine 700μmol/L more without dialysis is life-threatening is related to the cause of creatinine elevation and whether there are complications and other factors. If acute kidney injury causes elevated creatinine, after correcting reversible factors, renal function gradually recovered, at this time without dialysis may not be life-threatening; if chronic renal failure, at the same time combined with acute left heart failure and other complications, at this time without dialysis may be life-threatening. Creatinine 700μmol/L may be caused by acute kidney injury, or it may indicate that the patient enters into the stage of renal failure or even uremia. If acute kidney injury causes creatinine elevation, such as gastrointestinal fluid loss, massive blood loss and other pre-renal factors, after actively correcting the reversible factors, renal function may gradually recover, at this time without dialysis may not be life-threatening. If the patient has entered the stage of renal failure or even uremia, and at the same time combined with complications such as hyperkalemia that cannot be corrected by drugs, acute left heart failure, at this time without dialysis may be life-threatening. If patients find creatinine more than 700μmol/L, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of doctors.