Pimples are generally referred to as acne, a chronic inflammatory skin disease of the sebaceous glandular units of hair follicles. It can be treated with creams such as retinoids, antibiotics, benzoyl peroxide and azelaic acid. 1. Vitamin A acid class: including adapalene gel and vitamin A cream and other drugs. Initial use may cause local irritation reactions, such as erythema, flaking, tightness and burning sensation, and should be used in low concentration or in a small area away from light. 2. Antibiotics: topical preparations such as fusidic acid cream, erythromycin ointment, lincomycin and clindamycin and chloramphenicol. 3. Benzoyl peroxide: after topical application, it can slowly release new ecological oxygen and benzoic acid, which has the effect of killing Propionibacterium acnes, dissolving acne and astringent. A few patients will have mild skin irritation. 4. Azelaic acid: It has therapeutic effect on inflammation and acne, and can also reduce post-inflammatory hyperpigmentation. Its adverse reaction is localized mild erythema and tingling. Acne can be used externally more drugs, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor to use medication, do not take medication without authorization.