The liver is not only an important organ for the metabolism of proteins, fats and vitamins, but also an important site for glucose metabolism. After eating, the liver exerts its storage function to synthesize elevated blood glucose into liver glycogen and store it for emergency use, while inhibiting the conversion of other energy substances into sugar, and blood glucose returns to normal levels. When fasting blood sugar is too low, the liver can again break down the liver glycogen in its storehouse into glucose and accelerate the conversion of other substances into sugar to maintain normal blood sugar. When the liver functions abnormally, hepatic glycogen synthesis is impaired and blood glucose cannot be converted into hepatic glycogen for storage, causing blood glucose to remain at high levels and causing diabetes. In addition, the liver is also the main target organ for various hormones related to glucose metabolism and an important site for degradation. The liver also converts sugars into lipids and non-essential amino acids, regulating the various needs of the body. Once the liver is damaged for various reasons, our normal glucose metabolism function will be implicated and abnormal, causing an increase in blood glucose and the development of diabetes. Most patients with cirrhosis combined with glucose metabolism disorders do not have the typical symptoms of diabetes “three more, one less”, usually in the early stage, the fasting blood sugar of patients with cirrhosis combined with glucose metabolism abnormalities is normal, only the postprandial blood sugar rises to varying degrees, at this time, only through the screening of glucose tolerance test to make a clear diagnosis. The glucose tolerance test is to let patients measure blood glucose at half-hour, one-hour, two-hour and three-hour intervals after fasting and eating standard amount of glucose powder, in order to know the blood glucose concentration at different time points, once the patient’s postprandial blood glucose exceeds 7.8 mmmol/L and fasting blood glucose exceeds 5.6 mmmol/L at any one time point, it means abnormal glucose tolerance; the postprandial blood glucose exceeds 11.1 mmmol/L and fasting blood glucose over 6.1mmmol/L at any one time point can be diagnosed as diabetes mellitus. Since screening for abnormal glucose tolerance is not yet routinely practiced in clinical practice for patients with cirrhosis, it often leads to missed diagnoses. Some doctors often do not pay attention to abnormal glucose metabolism in cirrhosis, and often misuse drugs such as glucose and diuretics that aggravate glucose metabolism disorders and pancreatic β-cell burden, accelerating the progress of the disease. Some studies have found that patients with cirrhosis combined with diabetes mellitus differ significantly from those with ordinary diabetes mellitus in terms of clinical manifestations, regression, complications and mortality. The life expectancy of cirrhotic patients with combined diabetes will be affected because the risk of hepatocyte failure is greatly increased in the hyperglycemic state, which can aggravate the disease. The treatment of cirrhosis combined with abnormal glucose metabolism is very difficult, and most of the drugs commonly used in clinical treatment of diabetes are detrimental to liver function and are not suitable for the treatment of cirrhosis combined with diabetes. For patients with cirrhosis combined with diabetes mellitus, insulin therapy is recommended in principle, but due to the impaired liver glycogen reserve, insulin injection is more prone to hypoglycemic reactions than in general diabetic patients, and because it needs to be injected regularly and quantitatively every day, it is inconvenient to use, so its clinical application is somewhat limited. In view of the special characteristics of the treatment of cirrhosis combined with glucose metabolism abnormalities, we are carrying out a research project on the integrated treatment of cirrhosis combined with glucose metabolism abnormalities in Chinese and Western medicine. We will move the treatment of cirrhosis combined with diabetes to the stage of abnormal glucose tolerance, and combine Chinese and Western medicine to treat cirrhotic patients before they develop diabetes or in the early stage of diabetes, in order to reduce the chance of diabetes and delay the development of the disease. With the treatment of liver fibrosis as the focus, we start from improving liver function and give dietary guidance, so that patients can improve liver function and delay the progression of cirrhosis while correcting abnormal glucose metabolism, thus improving the quality of life and prolonging life.