Lipoprotein a over 400mg/L is more serious. The normal reference value of lipoprotein a is within 0~300mg/L. Elevated lipoprotein a can also be seen in type I diabetes mellitus, renal disease, inflammation, surgery, etc. or post-traumatic injury, so it is necessary to consult a doctor to find out the cause of the problem and carry out targeted diagnosis and treatment. At the same time, elevated lipoprotein a also has an important impact on the human body, and its atherosclerotic diseases such as coronary heart disease, cerebral infarction and other closely related to the onset of elevated levels of fibrin degradation can be inhibited to promote thrombosis. Therefore, when lipoprotein A reaches 400mg/L or more, it is more serious and requires intervention as soon as possible. To summarize, it is recommended to consult a doctor in time for standardized diagnosis and treatment.