Frequent recurrence of duodenal ulcer can be controlled or prevented by medication, general treatment and surgery. 1. Medication: Pantoprazole tablets, aluminum phosphate gel, bismuth pectin and other drugs can be applied under the guidance of physicians to treat the disease, the application of drugs must be in accordance with the doctor’s instructions and in accordance with the application of the treatment program, usually the course of treatment for about 4 to 8 weeks. 2. General treatment: patients must quit smoking, alcohol, etc., to avoid the influence of bad habits, daily need to eat regularly, regular and quantitative, avoid overeating; maintain a happy and good state of mind, regular sleep habits, and can be appropriate for exercise. 3. Surgical treatment: patients with complications (such as complications of gastrointestinal hemorrhage, chronic penetrating ulcer, acute perforation, etc.), and internal medicine treatment is ineffective need to undergo surgical treatment. Need to go to the hospital, by the physician according to the patient’s condition for targeted treatment, they can not just indiscriminate use of drugs.