Nausea without appetite is usually caused by chronic gastritis, viral hepatitis B, chronic cholecystitis and other diseases, different diseases treatment methods are different, you can follow the doctor’s instructions to take medication, surgery and other treatment. 1. Chronic gastritis: it is caused by Helicobacter pylori (Hp) infection, duodenal gastric reflux and other factors, most of the patients have no obvious symptoms, and those who have symptoms can have epigastric discomfort, lack of appetite, nausea, acid reflux and so on. Regular diet should be taken and overeating should be avoided; chronic gastritis caused by Hp infection can be treated with quadruple program as prescribed by doctor, i.e., two antibiotics (such as clarithromycin + amoxicillin and other combinations) + proton pump inhibitors (such as omeprazole, rabeprazole, etc.) + bismuth (such as colloidal bismuth pectin, etc.) to carry out eradication or oral domperidone, magnesium alumina carbonate, ranitidine and other symptomatic treatments. 2. Viral hepatitis B: It can also cause nausea, lack of appetite and other symptoms, and will be accompanied by fever, abdominal pain, yellow stain and other symptoms. Attention should be paid to rest, reasonable diet, and use ursodeoxycholic acid and reduced glutathione as prescribed by doctor to protect liver cells. Use interferon alpha, entecavir, etc. to inhibit viral replication. For patients with advanced hepatitis and cirrhosis, liver transplantation can be considered. 3. Chronic cholecystitis: mostly due to gallbladder stones, bacterial infection, symptoms are often atypical, patients have a history of biliary colic, and then there are symptoms of dyspepsia such as lack of appetite, bloating, nausea. Sensitive bacterial antibiotics, such as clindamycin and cefotaxime, can be used as prescribed by the doctor to control inflammation, or surgical removal of the gallbladder can be performed. In addition, depression, gastric cancer, cirrhosis and other diseases can also cause this phenomenon, and patients are advised to go to the hospital in a timely manner to identify the cause of the disease and receive treatment as soon as possible.