Varicella and 13-valent pneumonia vaccine are not recommended to be given together. Both chickenpox vaccine and 13-valent pneumonia vaccine may cause corresponding adverse reactions, the two vaccines together may affect the judgment of which vaccine is the adverse reaction, and at the same time, if there is a superposition of adverse reactions, it may cause aggravation of symptoms. As the body will undergo the corresponding immune response after chickenpox vaccination, which makes the body’s ability to resist diseases decrease, if it is given together with 13-valent pneumonia vaccine, it may increase the incidence of adverse reactions of the two vaccines, and it may also affect the effect of the two vaccines. Therefore, chickenpox and 13-valent pneumonia vaccine are not recommended to be given together. When chickenpox and 13-valent pneumonia vaccine need to be injected, it is necessary to actively listen to the arrangement of professional doctors and take the injection under the guidance of doctors.