Wine contains ethanol, cephalosporin infusion drinking alcohol may cause disulfiram-like reaction, mostly occurring in the medication and exposure to ethanol products five minutes to one hour after the appearance, due to certain metabolic reactions in the body to appear impaired, but also in the medication within a week of exposure to alcohol appeared. Mildly, facial flushing, headache, nausea, chest tightness, etc., and in severe cases, there may be a drop in blood pressure and other changes, and even death. Therefore, it is recommended that when using cephalosporins such as cefuroxime sodium, alcohol and alcohol-containing drugs, food, etc. are prohibited for 7 days after administration to avoid disulfiram-like reactions. Other drugs such as nitroimidazoles metronidazole, etc., hypoglycemic class such as metformin, etc. exposure to ethanol may cause disulfiram-like reaction, should also be avoided. The above drugs are recommended to be used under the guidance of a doctor in a rational and standardized manner to avoid adverse consequences.