Each tablet of Ursine contains the same dose of the drug, so the effect is the same regardless of the order in which it is taken. Some people may experience side effects such as nausea and vomiting when taking this medication, so it can be taken at night before going to bed. You must not forget to take it. In case you forget to take it the night before, you can make it up the next morning which is within twelve hours, otherwise it will not only affect the effect of contraception, but also cause vaginal bleeding. In the case of Eusebio you have to take it in order, because Eusebio has 4 white pills inside, which contain a different dose than the other pills, and is only a placebo, so you just have to follow it.