Glutamic oxalyl and glutamic alanine aminotransferase are two important enzyme profile indicators for liver function testing, which generally accurately reflect hepatocellular injury and impaired liver function. High glutamic oxalyl and glutamic alanine aminotransferases can be caused in physiological or pathological conditions. Physiological causes include poor rest, late nights, overeating, strenuous exercise, and eating high fats. For pathological causes, including medical and surgical causes, such as fatty liver, alcoholic liver, drug-related liver damage, bile duct stones inside and outside the liver, hepatobiliary tumors, liver abscesses, huge hepatic hemangiomas and liver cysts compressing the liver, causing liver tissue damage, as well as autoimmune liver disease can cause high glutathione and glutamate aminotransferases, which require further clarification of the cause and targeted treatment.