Estradiol is the main component of estrogen, which has the effect of promoting the development of the reproductive system and maintaining and promoting bone metabolism. Low estradiol in women may cause osteoporosis, irregular menstruation, premature ovarian failure and other harmful effects. 1. Osteoporosis: Calcium and phosphorus salts are deposited in the bone in order to maintain normal bone quality. Therefore, women with low estradiol may have abnormal calcium metabolism, which may cause osteoporosis and other bone diseases. 2. Irregular menstruation: If female patients have low estradiol, the secretion of sex hormones in the body will be out of balance. It will affect the shedding of the uterine lining, and abnormal menstrual cycle and bleeding will occur. 3. Premature Ovarian Failure: Estradiol has a certain effect on female ovarian function, which can cause ovarian anovulation or low follicular maturity, and in serious cases, it can lead to premature ovarian failure. If a woman has low estradiol, it is recommended that she should consult a doctor in time, follow the doctor’s instructions to choose the appropriate examination method, clarify the cause with the doctor’s help, and carry out targeted treatment or therapy.