Gastroscopy with tissue biopsy is an important tool for early detection of gastric cancer, and gastroscopy should be performed in time for the following conditions, and some patients even need long-term and regular re-examination of gastroscopy: 1.Symptoms such as upper abdominal fullness, acid reflux, burping and belching for a long time; 2.Poor appetite, loss of appetite, weakness and weight loss; Hu Jiankun, Department of Gastroenterology, West China Hospital; 3.Nausea and even vomiting; 4.Difficulty in swallowing; 5.Black stool or 6.Unexplained anemia; 7.Past history of gastritis or gastric ulcer and recent aggravation of upper abdominal pain or discomfort; 8.History of ulcer over 40 years old; 9.Family history over 40 years old; 10.Regular review after gastric surgery; 11.Other conditions that need to exclude gastric diseases. In recent years, gastric cancer has a tendency to become younger, so attention should be paid to learning to relieve work and study pressure, eating and sleeping regularly, and seeking medical consultation in time when discomfort occurs. At the same time, we should pay attention to multi-point tissue biopsy of suspicious areas during gastroscopy, and should not blindly judge it as gastritis or gastric ulcer without tissue biopsy to avoid delaying the diagnosis.