There is no special antidote for phenobarbital poisoning, and the methods of rescue after poisoning are as follows: 1. Stop the drug, go on cardiac monitoring, closely observe the patient’s respiration, blood pressure, heartbeat, pulse rate oxygen saturation and other vital signs, give the patient oxygen, intubate the trachea on the ventilator if the breathing is not good, rehydrate quickly if the blood pressure is low, use naloxone to promote awakening if it is not possible, and use naloxone if the mind is confused. 2. The earlier and more thorough the gastric lavage, the better the effect. After gastric lavage, instill activated carbon adsorption through the gastric lavage tube, and then use the laxative sodium sulfate to induce diarrhea, so that the phenobarbital that has not been absorbed into the bloodstream can be removed from the gastrointestinal tract as much as possible. Phenobarbital that has been absorbed into the blood can be given a large amount of fluids, diuretic with the strong diuretic furosemide, alkaline drug sodium bicarbonate to alkalize the urine to speed up the discharge of phenobarbital from the urine, patients with severe poisoning and bad condition can be put on blood purification to directly remove phenobarbital from the blood. 3, symptomatic treatment, such as correction of cerebral edema, pulmonary edema, renal failure, acid-base electrolyte imbalance, etc.