Small blisters on the glans area, if accompanied by pain, discomfort, clinical manifestations of erythema on the emergence of clusters, dense blisters, most likely is the type 2 herpes simplex virus infection after the genital herpes. Genital herpes is one of the sexually transmitted diseases, and can be treated with oral antiviral drugs, such as valacyclovir hydrochloride, and topical antiviral treatment by spraying Penciclovir cream. The use of drugs can significantly shorten the course of the disease and reduce the patient’s painful and uncomfortable self-conscious symptoms. Once the disease is diagnosed, it is difficult to completely eradicate, and only symptomatic treatment can be chosen. The reason is that once the immunity is lowered, the genital herpes virus hidden in the spinal nerve root will be activated again, thus leading to the recurrence of the disease. It is also possible that excessive friction leads to localized violent injuries, because men will frequently rub the penis during masturbation or sex and accidentally injure the penile subcutis, which may lead to oozing of tissue fluid and the development of small blisters, usually accompanied by severe pain.