The consequences of high thyroid stimulating hormone need to be judged according to the cause of the disease. Common causes of high thyroid stimulating hormone may be caused by hypothyroidism or pituitary tumors, which may result in chills and fatigue. 1. Hypothyroidism: When the thyroid stimulating hormone is high and at the same time the thyroid hormone level decreases significantly, it belongs to hypothyroidism. It will cause a decrease in metabolic rate, as well as a decrease in sympathetic excitability, such as memory loss, weight gain, constipation, and chills. In severe cases, there is hypothyroidism mucous edema coma, which needs timely treatment. 2. Pituitary tumor: Pituitary tumor can also cause high thyroid stimulating hormone, leading to hyperthyroidism related symptoms, such as fear of heat, palpitations, irritability, hyper appetite, etc., there may also be pituitary tumor compression related symptoms such as headache, visual field defects. Untreated hyperthyroidism may be life-threatening. When patients with high thyrotropin, they should go to the hospital in time to further clarify the cause of the disease, and actively treat under the guidance of the doctor to avoid aggravation of the symptoms and serious consequences.