Prostate PSA belongs to prostate specific antigen, prostate PSA normal range in 0-4ng/mL, prostate PSA value of 8.5ng/mL is high, can suggest that there are nodules, may be benign nodules, may be malignant nodules, usually with prostatitis, prostate hyperplasia, prostate cancer. 1. Prostatitis: It is an inflammation that occurs in the prostate gland, and the stimulation of inflammation may lead to high PSA value and cause inflammatory nodules, after the inflammation is eliminated, the nodules may shrink and the PSA value will also decrease. 2. Prostatic hyperplasia: Prostatic hyperplasia is one of the common diseases in middle-aged and old-aged men, and it is known that benign prostatic hyperplasia must have two conditions: functional testicles and aging. Prostatic hyperplasia may also result in high PSA values and prostate nodules. 3. Prostate cancer: belonging to malignant tumors in the prostate gland, usually the PSA value will rise significantly, accompanied by prostate nodules. If the PSA value of prostate is high and accompanied by nodules, it is recommended to consult the doctor in time and exclude malignant lesions through pathological examination.