Children with severe toothache at night may be due to physiological factors, at this time no special treatment; if it is due to pathological factors, such as dental caries or periodontitis, etc., the use of medication. 1. Physiological factors: due to children usually do not pay attention to dietary adjustments, eating too hot or too cold food, etc., stimulate the dental nerve caused. Parents are advised to instruct children to rinse their mouths with warm water and brush their teeth with desensitizing toothpaste to help improve the symptoms of toothache; if the pain is caused by the eruption of permanent teeth during the children’s tooth replacement period, it is recommended to maintain oral hygiene and avoid undesirable stimuli to alleviate the pain; 2. Pathological factors: due to dental caries or periodontitis caused by children, it is recommended to consult a doctor in a timely manner, in accordance with the doctor’s instructions for regular disinfection and medication to remove the necrotic part of the tooth, while taking anti-infective drugs, such as amoxicillin capsules to alleviate the need to comply with the doctor’s instructions to take painkillers acetaminophen oral solution to alleviate and improve the child’s above symptoms. Parents are advised to keep the child’s diet light during the treatment period, avoid eating raw, cold, hard and spicy food, and do a good job of daily oral care.