Postpartum depression refers to a series of manifestations such as low mood and lack of interest in life after childbirth. The manifestations of postpartum depression may vary in mothers, and it is recommended to go to a psychiatry department for counseling if there are severe manifestations of depression. There are some newborns who need to be transferred to neonatology for treatment after birth due to pathologic factors. Mothers and their families are full of expectations for the prognosis of their newborns, and it is often difficult to accept the newborns when they have complications, and coupled with the fact that they can’t see their children, postpartum depression may occur. It is recommended that mothers should adjust their mindset positively. At present, the medical development of neonatology and obstetrics is relatively advanced, and the prognosis of most newborns is relatively good, so there is no need to worry too much, and in the first 42 days after delivery, most of the hormone levels in the body can return to normal, and most of the postpartum depression can be relieved.