SLE is a chronic autoimmune disease involving multiple systems and organs. Its clinical symptoms are diverse, and early symptoms are often atypical, with fever, rash, arthritis or arthralgia being the most common. Most of the patients with SLE have insidious onset and complex and variable symptoms. About 90% of patients have fever at the initial stage, usually low or moderate fever, and high fever can be seen in the acute stage; about 80% of patients have skin and mucous membrane lesions, typically butterfly-shaped erythema on the face, symmetrical rash or disc-shaped erythema on exposed areas. In addition, arthritis or arthralgia is also one of the common symptoms, often presenting with symmetrical multi-joint pain and swelling, with finger, wrist and knee joints being the most common. It should be noted that in addition to the first symptoms mentioned above, some patients with SLE may also have systemic manifestations such as fatigue, weakness, loss of appetite, wasting, or impairment of urinary and hematological systems such as occult nephritis, hypocellularity, mild anemia, thrombocytopenia, etc. as the first clinical manifestations. Therefore, the early symptoms of SLE are complex and varied, and lack clinical specificity, which may lead to missed diagnosis and delayed diagnosis. Therefore, women of childbearing age and those with a family history of lupus should consider the possibility of SLE if they develop symptoms and signs involving multiple system organs that are difficult to be explained by conventional diseases, and should be promptly diagnosed and treated.