The most common causes of ankle swelling are localized and systemic causes. Local causes are common in trauma, arthritis, infection, etc. Systemic causes are common in hepatic, renal and cardiac edema. 1. Local causes (1) Spraining the ankle joint in daily life or forming traumatic arthritis can cause symptoms such as swelling or edema at the ankle. (2) Rheumatoid arthritis, gouty arthritis and other joint diseases can also cause swelling and pain in the ankle due to the non-infectious inflammatory reaction in the joint or the presence of gout stones in the ankle joint. (3) Infectious diseases such as septic arthritis can also be caused. In addition to swelling in the ankle joint, this type of disease can also be accompanied by severe pain and other symptoms. 2. Systemic causes (1) Hepatogenic edema: such as cirrhosis and liver failure caused by various liver diseases, ankle swelling can occur. (2) Nephrogenic edema: such as suffering from nephritis, renal failure, nephrotic syndrome, IgA nephropathy and other diseases, can also cause ankle edema. (3) Cardiogenic edema: cardiogenic edema caused by aggravation of various underlying heart diseases, such as heart failure, can present ankle edema symptoms. There may be other causes of ankle edema, it is recommended to go to the regular hospital in time, follow the doctor’s instructions to improve the examination and symptomatic treatment.